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148016-81-3 (Doripenem free base)
CAS Number: 53-16-7
11-trihydrogenio-1
pp 531-536
whereas the parent compound was weakly active
Ertapenem (sodium salt) 17881 148016-81-3 (Doripenem free base)Ertapenem, the first group of carbapenems, is a 1 methyl carbapenem with potent in vitro activity against a broad spectrum of bacterial pathogens including Gram positive and Gram negative aerobic and anaerobic pathogens . In vitro: In E. coli, ertapenem binds to penicillin binding proteins (PBPs) 1a, 1b, 2, 3, 4 and 5, showing highest affinity for PBPs 2 and 3 . MIC90s for most species of Enterobacteriaceae were < 1 mg L. MIC90s for most Bacteroides
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